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Full title & acronym: Understanding lipid immunometabolism to treat disease (UNLIMITED).
Duration: 2025–2029 (48 months).
Partners & funding amounts: Consortium led by L. Berod, D. Sancho, B. Everts, J. van den Boosche et al.; amount for team: 314 k€; consortium total ≈ 4.5 M€.
Responsibilities: Co-PI; WP1 leader; organizer of doctoral MSCA-DN workshop in Marseille.
Theme & content of work: Trains 14 PhDs in lipid immunometabolism using single-cell/spatial metabolomics and SCENITH-family methods, with your node focusing on spatial metabolism during glycolytic stress and its epigenetic readouts.
Scope & impact: EU-wide capacity building and standardization of human-centric functional metabolism tools feeding precision therapies.

Development of the next-Generation Lab: Building the Toolbox for Lipid Immune Metabolism Research (RO1; DC1/CNRS-CIML; DC2/AUMC; DC3/UMCM; DC4/UP; DC5/VG; BC). DC1/CIML (Metabolic Regulation of Immunity – WP1 leader: Argüello RJ)

Publications

2020
Argüello RJ, Combes AJ, Char R, Gigan JP, Baaziz AI, Bousiquot E, Camosseto V, Samad B, Tsui J, Yan..., SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution., Cell Metab 2020 Dec; 32(6): 1063-1075.e7.
2024
Jason Cosgrove, Antoine Marçais, Felix Hartmann, Andreas Bergthaler, Ivan Zanoni, Mauro Corrado, Le..., Unlocking Single-Cell Immunometabolism Research: A Call for Accessible Tools, <i>Nature Metabolism</i>, 2024, 6 (5), pp.779-782. <a target="_blank" href="https://dx.doi.org/10.1038/s42255-024-01031-w">⟨10.1038/s42255-024-01031-w⟩</a>.

Financement