Felipe FLORES SANTIBANEZ – CIML

Recherche

Thème

Dorian BOURGEON

À propos

I am an engineer in Biotechnology with an MSc and PhD in Cellular and Molecular Biology. I completed my PhD in the laboratory of Prof. Fabiola Osorio at the University of Chile, where I studied the role of the Unfolded Protein Response sensor IRE1α in regulating tumor-associated conventional dendritic cells (cDCs).

In 2024, I joined CIML as a postdoctoral fellow. My main project focuses on the immunometabolic and epigenetic characterization of sepsis patients, with the goal of identifying markers and mechanisms that could help predict the immune dysregulation syndrome affecting sepsis survivors. This work is part of the BEATsep consortium (https://www.beatsepsis.eu/), a collaborative effort involving several laboratories and clinicians in an interdisciplinary and big-data approach to address the long-term immunological consequences of sepsis.

Projets

Epic-SCENITH: regulators of metabolism and epigenetics in glioblastoma-associated myeloid cells

Duration: 2021–2025.Partners & funding amounts: APHM/La Timone (E. Tabouret); amount for team: 325 k€.Responsibilities: PI–coordinator (only beneficiary)Theme & content of […]

Rafael J ARGUELLO

MetaNiche (Spatial-SCENITH) Metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02).

Bone marrow metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02). Duration: 2023–2027 (42 months).Partners & funding amounts: Institut Curie (L. Perié), Institut […]

Rafael J ARGUELLO

Biomarkers established to stratify sepsis long-term adverse effects to improve patients’ survivorship (BEATsep)

Full title & acronym: Biomarkers established to stratify sepsis long-term adverse effects to improve patients’ survivorship (BEATsep).Duration: 2024–2029 (60 months).Partners […]

Rafael J ARGUELLO

UNLIMITED – MSCA doctoral network UNLIMITED (Europe)

Full title & acronym: Understanding lipid immunometabolism to treat disease (UNLIMITED).Duration: 2025–2029 (48 months).Partners & funding amounts: Consortium led by […]

Rafael J ARGUELLO

IMAGINe – High Risk High Gain IMAGINe (France)

Targeting intratumor metabolic heterogeneity in neuroblastoma to develop innovative treatments (IMAGINe) Type: National.Duration: 2024–2029 (48 months).Partners & funding amounts: CRCM […]

Rafael J ARGUELLO

South-ROCK – SIRIC

South-Research On Cancer for Kids. INCA Pediacriex (France) Type: National (integrated cancer site).Full title & acronym: South-Research On Cancer for […]

Rafael J ARGUELLO

Publications

Julien Gigan, Paulina Garcia-Gonzalez, Lou Galliot, Alexandre Reynaud, Yoan Ghaffar, Eve Seillier, R..., Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR): A Novel Method revealing bortezomib resistance mechanisms in Multiple Myeloma, 2024.

Flores-Santibañez F, Rennen S, Fernández D, De Nolf C, Van De Velde E, Gaete González S, Fuentes ..., Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity., Front Immunol 2023 ; 14(): 1209588.

Rafael J Argüello, Profiling energetic metabolism and epigenetics by Flow cyometry, <i>4th Edition: Metabolism and Cancer. https://www.metabolism-cancer.com/program/</i>, May 2021, Bordeaux, France.

Flores-Santibáñez F, Cuadra B, Fernández D, Rosemblatt MV, Núñez S, Cruz P, Gálvez-Cancino F, ..., In Vitro-Generated Tc17 Cells Present a Memory Phenotype and Serve As a Reservoir of Tc1 Cells In Vivo., Front Immunol 2018 ; 9(): 209.

Bono MR, Tejon G, Flores-Santibañez F, Fernandez D, Rosemblatt M, Sauma D, Retinoic Acid as a Modulator of T Cell Immunity., Nutrients 2016 Jun; 8(6): .

Bono MR, Fernández D, Flores-Santibáñez F, Rosemblatt M, Sauma D, CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression., FEBS Lett 2015 Nov; 589(22): 3454-60.

Tejón G, Manríquez V, De Calisto J, Flores-Santibáñez F, Hidalgo Y, Crisóstomo N, Fernández D,..., Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation., Biomed Res Int 2015 ; 2015(): 137893.