Romain RONCAGALLI – CIML

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À propos

R. Roncagalli a obtenu son PhD en biologie moléculaire en 2007, dans le laboratoire d’André Veillette à l’Université de Montréal (Canada). Il y a étudié de nouvelles classes d’adaptateurs moléculaires (famille SAP) et de récepteurs (famille SLAM) et a démontré le rôle biologique fondamental de ces protéines dans les cellules NK.
En tant que chercheur postdoctoral, il a ensuite rejoint l’équipe de Bernard et Marie Malissen au Centre d’Immunologie de Marseille-Luminy (CIML) pour travailler sur la signalisation des lymphocytes T. En 2010, R. Roncagalli a obtenu un poste permanent de chargé de recherche (CR) au CNRS afin de développer et d’étudier des modèles expérimentaux qui ont largement contribué à modifier notre compréhension fondamentale de l’activation des lymphocytes T.
Depuis 2024, Romain Roncagalli est responsable de l’équipe « Biologie intégrative des lymphocytes T », qui travaille sur les mécanismes moléculaires à l’origine de l’activation des lymphocytes T en utilisant des approches expérimentales combinant génétique murine, biologie des systèmes, modélisation et analyses par spectrométrie de masse.

Publications

Zhang F, Celis-Gutierrez J, Zhang L, Mellado V, Gelard L, Panigot S, Mori D, Lu L, Voisinne G, Vilar..., A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo., J Exp Med 2025 Aug; 222(8): .

Ruminski K, Celis-Gutierrez J, Jarmuzynski N, Maturin E, Audebert S, Malissen M, Camoin L, Voisinne ..., Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway., Front Immunol 2023 ; 14(): 1139123.

Voisinne G, Locard-Paulet M, Froment C, Maturin E, Menoita MG, Girard L, Mellado V, Burlet-Schiltz O..., Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination., Nat Immunol 2022 Sep; 23(9): 1355-1364.

Li B, Lu Y, Zhong MC, Qian J, Li R, Davidson D, Tang Z, Zhu K, Argenty J, de Peredo AG, Malissen B, ..., Cis interactions between CD2 and its ligands on T cells are required for T cell activation., Sci Immunol 2022 Aug; 7(74): eabn6373.

Zhai Y, Celis-Gutierrez J, Voisinne G, Mori D, Girard L, Burlet-Schiltz O, de Peredo AG, Roncagalli ..., Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics., Cell Mol Immunol 2021 Jun; 18(6): 1581-1583.

Mori D, Grégoire C, Voisinne G, Celis-Gutierrez J, Aussel R, Girard L, Camus M, Marcellin M, Argent..., The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation., J Exp Med 2021 Feb; 218(2): .

Locard-Paulet M, Voisinne G, Froment C, Goncalves Menoita M, Ounoughene Y, Girard L, Gregoire C, Mor..., LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions., Mol Syst Biol 2020 Jul; 16(7): e9524.

Voisinne G, Kersse K, Chaoui K, Lu L, Chaix J, Zhang L, Goncalves Menoita M, Girard L, Ounoughene Y,..., Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics., Nat Immunol 2019 Nov; 20(11): 1530-1541.

Celis-Gutierrez J, Blattmann P, Zhai Y, Jarmuzynski N, Ruminski K, Grégoire C, Ounoughene Y, Fiore ..., Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy., Cell Rep 2019 Jun; 27(11): 3315-3330.e7.

Stéphanie Gon, Marie Loosveld, Thomas Crouzet, Delphine Potier, Mélanie Bonnet, Stéphanie Morin, ..., Fit αβ T-Cell Receptor suppresses leukemogenesis of Pten-deficient thymocytes., <i>Haematologica</i>, 2018, <a target="_blank" href="https://dx.doi.org/10.3324/haematol.2018.188359">⟨10.3324/haematol.2018.188359⟩</a>.

Roncagalli R, Cucchetti M, Jarmuzynski N, Grégoire C, Bergot E, Audebert S, Baudelet E, Menoita MG,..., The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells., J Exp Med 2016 Oct; 213(11): 2437-2457.

Voisinne G, García-Blesa A, Chaoui K, Fiore F, Bergot E, Girard L, Malissen M, Burlet-Schiltz O, Go..., Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation., Mol Syst Biol 2016 Jul; 12(7): 876.

Bounab Y, Anne-Marie-Hesse , Iannascoli B, Grieco L, Couté Y, Niarakis A, Roncagalli R, Lie E, Lam ..., Proteomic Analysis of the SH2 Domain-containing Leukocyte Protein of 76 kDa (SLP76) Interactome in Resting and Activated Primary Mast Cells., Mol Cell Proteomics 2014 Feb; 13(2): 678.

Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek ..., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells., Nat Immunol 2013 Aug; 14(8): 858-66.

Roncagalli R, Mingueneau M, Grégoire C, Langlet C, Malissen B, Malissen M, Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes., Semin Immunopathol 2010 Jun; 32(2): 117-25.

Mingueneau M, Sansoni A, Grégoire C, Roncagalli R, Aguado E, Weiss A, Malissen M, Malissen B, The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes., Nat Immunol 2008 May; 9(5): 522-32.