Paulina GARCIA GONZALEZ – CIML

Recherche

Thème

Dorian BOURGEON

À propos

Je suis scientifique spécialisée en immunologie, avec un MSc en biochimie et un PhD en sciences biomédicales. Mon parcours scientifique s’est construit autour de la compréhension des mécanismes qui régulent la réponse immunitaire dans différents contextes pathologiques, allant de l’auto-immunité au cancer.

Actuellement, je suis chercheuse post-doctorante au CIML, où j’explore les interactions entre métabolisme, épigénétique et immunité dans le glioblastoma et la leucémie aiguë myéloïde. Mes projets visent principalement à étudier comment le crosstalk entre le microenvironnement tumoral et les cellules immunitaires façonne la réponse antitumorale, de la différenciation cellulaire à la fonction, avec pour objectif d’identifier des cibles métaboliques susceptibles d’aider à prédire la réponse aux thérapies et l’évolution de la maladie.

Projets

Epic-SCENITH: regulators of metabolism and epigenetics in glioblastoma-associated myeloid cells

Duration: 2021–2025.Partners & funding amounts: APHM/La Timone (E. Tabouret); amount for team: 325 k€.Responsibilities: PI–coordinator (only beneficiary)Theme & content of […]

Rafael J ARGUELLO

MetaNiche (Spatial-SCENITH) Metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02).

Bone marrow metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02). Duration: 2023–2027 (42 months).Partners & funding amounts: Institut Curie (L. Perié), Institut […]

Rafael J ARGUELLO

Biomarkers established to stratify sepsis long-term adverse effects to improve patients’ survivorship (BEATsep)

Full title & acronym: Biomarkers established to stratify sepsis long-term adverse effects to improve patients’ survivorship (BEATsep).Duration: 2024–2029 (60 months).Partners […]

Rafael J ARGUELLO

INCa PL-Bio CARaïbes

Anti-GD3 CAR-NK cells to overcome therapeutic resistance in glioblastoma (CARaïbes). Type: National.Duration: 2025–2029 (48 months).Partners & funding amounts: INP-APHM (E. […]

Rafael J ARGUELLO

IMAGINe – High Risk High Gain IMAGINe (France)

Targeting intratumor metabolic heterogeneity in neuroblastoma to develop innovative treatments (IMAGINe) Type: National.Duration: 2024–2029 (48 months).Partners & funding amounts: CRCM […]

Rafael J ARGUELLO

TALETE (Transcan-3 ERA-NET, Europe)

Targeting acute myeloid leukemia immunosuppressive microenvironment by combined IDO1 inhibition and PD-1 blockade Type: European.Duration: 2023–2027 (36 months).Partners & funding […]

Rafael J ARGUELLO

South-ROCK – SIRIC

South-Research On Cancer for Kids. INCA Pediacriex (France) Type: National (integrated cancer site).Full title & acronym: South-Research On Cancer for […]

Rafael J ARGUELLO

Publications

Julien Gigan, Paulina Garcia-Gonzalez, Lou Galliot, Alexandre Reynaud, Yoan Ghaffar, Eve Seillier, R..., Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR): A Novel Method revealing bortezomib resistance mechanisms in Multiple Myeloma, 2024.

Essakhi N, Bertucci A, Baeza-Kallee N, Colin C, Lavignolle-Heguy R, Garcia-Gonzalez P, Argüello RJ,..., Metabolic adaptation of myeloid cells in the glioblastoma microenvironment., Front Immunol 2024 ; 15(): 1431112.

Carine Jiguet-Jiglaire, Sebastien Boissonneau, Emilie Denicolai, Victoria Hein, Romain Lasseur, Jose..., Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study, <i>Acta Neuropathologica Communications</i>, 2022, 10 (1), pp.1. <a target="_blank" href="https://dx.doi.org/10.1186/s40478-021-01305-4">⟨10.1186/s40478-021-01305-4⟩</a>.

Rafael J Argüello, Profiling energetic metabolism and epigenetics by Flow cyometry, <i>4th Edition: Metabolism and Cancer. https://www.metabolism-cancer.com/program/</i>, May 2021, Bordeaux, France.

Gárate D, Rojas-Colonelli N, Peña C, Salazar L, Abello P, Pesce B, Aravena O, García-González P,..., Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis., Arthritis Rheum 2013 Jan; 65(1): 120-9.