Achille BROGGI – CIML

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Thème

À propos

Dr Broggi. a obtenu son doctorat en médecine translationnelle en 2012 dans le laboratoire de Francesca Granucci à l’Université de Milan-Bicocca, où il a étudié la tolérance périphérique des lymphocytes T et le rôle du facteur de transcription NFAT dans les phagocytes.

En 2015, il a rejoint le laboratoire d’Ivan Zanoni au Boston Children’s Hospital en tant que chercheur postdoctoral. Il y a mis en évidence une nouvelle fonction immunomodulatrice de l’IFN-λ, qui inhibe l’activation des neutrophiles et protège les barrières muqueuses lors de l’inflammation intestinale.

À partir de 2018, en tant qu’Instructor, il a également étudié le rôle des interférons dans le système respiratoire et décrit comment l’IFN-λ peut altérer la réparation tissulaire après une pneumonie virale aiguë.

En 2021, Achille a rejoint le CIML, où il poursuit ses recherches sur les réponses aux interférons en tant que régulateurs clés de la biologie des muqueuses, et plus particulièrement sur la régulation de la barrière intestinale.

Actualités

L'inflammation contrôle-t-elle la guérison intestinale ? Une nouvelle découverte identifie une cible thérapeutique prometteuse pour les patients atteints de maladies inflammatoires de l'intestin

Une équipe de chercheurs du Centre d’Immunologie de Marseille-Luminy (CIML), dirigée par le Dr Achille Broggi, en collaboration avec le […]

Projets

MetaNiche (Spatial-SCENITH) Metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02).

Bone marrow metabolic niches regulate hematopoiesis (MetaNiche, ANR-22-CE15-0015-02). Duration: 2023–2027 (42 months).Partners & funding amounts: Institut Curie (L. Perié), Institut […]

Rafael J ARGUELLO

Publications

Millet V, Gensollen T, Maltese M, Serrero M, Lesavre N, Bourges C, Pitaval C, Cadra S, Chasson L, Vu..., Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis., Gut 2023 Jun; 72(6): 1115-1128.

Steeve Boulant, Adriana Forero, Deanna M Santer, Achille Broggi, Editorial: Type III interferons: Emerging roles beyond antiviral barrier defense, <i>Frontiers in Immunology</i>, 2022, 13, <a target="_blank" href="https://dx.doi.org/10.3389/fimmu.2022.1030812">⟨10.3389/fimmu.2022.1030812⟩</a>.

Valentina Poli, Victor Pui-Yan Ma, Marco Di Gioia, Achille Broggi, Mehdi Benamar, Qian Chen, Ralph M..., Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation, <i>iScience</i>, 2021, 24 (11), pp.103256. <a target="_blank" href="https://dx.doi.org/10.1016/j.isci.2021.103256">⟨10.1016/j.isci.2021.103256⟩</a>.

Benedetta Sposito, Achille Broggi, Laura Pandolfi, Stefania Crotta, Nicola Clementi, Roberto Ferrare..., The interferon landscape along the respiratory tract impacts the severity of COVID-19, <i>Cell</i>, 2021, 184 (19), pp.4953-4968.e16. <a target="_blank" href="https://dx.doi.org/10.1016/j.cell.2021.08.016">⟨10.1016/j.cell.2021.08.016⟩</a>.

Hani Harb, Mehdi Benamar, Peggy Lai, Paola Contini, Jason Griffith, Elena Crestani, Klaus Schmitz-Ab..., Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections, <i>Immunity</i>, 2021, 54 (6), pp.1186-1199.e7. <a target="_blank" href="https://dx.doi.org/10.1016/j.immuni.2021.04.002">⟨10.1016/j.immuni.2021.04.002⟩</a>.

Sposito B, Broggi A, Pandolfi L, Crotta S, Ferrarese R, Sisti S, Clementi N, Ambrosi A, Liu E, Frang..., Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients., bioRxiv 2021 Mar; (): .

Broggi A, Ghosh S, Sposito B, Spreafico R, Balzarini F, Lo Cascio A, Clementi N, De Santis M, Mancin..., Type III interferons disrupt the lung epithelial barrier upon viral recognition., Science 2020 Aug; 369(6504): 706-712.

Broggi A, Granucci F, Zanoni I, Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion., J Exp Med 2020 Jan; 217(1): .

Liu NN, Uppuluri P, Broggi A, Besold A, Ryman K, Kambara H, Solis N, Lorenz V, Qi W, Acosta-Zaldíva..., Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence., PLoS Pathog 2018 Jul; 14(7): e1007076.

Broggi A, Tan Y, Granucci F, Zanoni I, IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function., Nat Immunol 2017 Oct; 18(10): 1084-1093.

, Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems., Sci Immunol 2017 Sep; 2(15): .

Zanoni I, Granucci F, Broggi A, Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs., Front Immunol 2017 ; 8(): 1661.

Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan..., An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells., Science 2016 Jun; 352(6290): 1232-6.

Broggi A, Cigni C, Zanoni I, Granucci F, Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions., J Vis Exp 2016 Apr; (110): e52589.

Broggi A, Granucci F, Microbe- and danger-induced inflammation., Mol Immunol 2015 Feb; 63(2): 127-33.

Bissa M, Pacchioni SM, Zanotto C, De Giuli Morghen C, Illiano E, Granucci F, Zanoni I, Broggi A, Rad..., Systemically administered DNA and fowlpox recombinants expressing four vaccinia virus genes although immunogenic do not protect mice against the highly pathogenic IHD-J vaccinia strain., Virus Res 2013 Dec; 178(2): 374-82.

Broggi A, Zanoni I, Granucci F, Migratory conventional dendritic cells in the induction of peripheral T cell tolerance., J Leukoc Biol 2013 Nov; 94(5): 903-11.

Zanoni I, Spreafico R, Bodio C, Di Gioia M, Cigni C, Broggi A, Gorletta T, Caccia M, Chirico G, Siro..., IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions., Cell Rep 2013 Sep; 4(6): 1235-49.

Caterina Vitali, Francesca Mingozzi, Achille Broggi, Simona Barresi, Francesca Zolezzi, Jagadeesh Ba..., Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells, <i>Blood</i>, 2012, 120 (6), pp.1237-1245. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2011-09-379776">⟨10.1182/blood-2011-09-379776⟩</a>.

Zanoni I, Ostuni R, Barresi S, Di Gioia M, Broggi A, Costa B, Marzi R, Granucci F, CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice., J Clin Invest 2012 May; 122(5): 1747-57.

Zanoni I, Bodio C, Broggi A, Ostuni R, Caccia M, Collini M, Venkatesh A, Spreafico R, Capuano G, Gra..., Similarities and differences of innate immune responses elicited by smooth and rough LPS., Immunol Lett 2012 Feb; 142(1-2): 41-7.