Projet: Investigating the role of endosomal dynamic modulators during immune dysregulation and neurodegenerative pathology – IMPACT Sensors

À propos

Project : IMPACT Sensors

Other participants : IGBMC, Strasbourg (Nicolas Charlet-Berguerand) and Institut Curie, Paris (Franck Perez). Duration 2025 – 2029 (48 mois)

This project explores how vesicle trafficking controls the transport and activation of nucleic acid sensors in mammalian cells. Dysregulation of these pathways drives inflammation and neurodegeneration. We will investigate the role of C9ORF72 and associated GTPases in receptor triage to endolysosomes, using advanced live-cell imaging and innovative cellular and animal models. By dissecting the dynamics of receptor mobility and signaling, this work aims to uncover the physiological mechanisms governing innate immune responses and their impact on this disease, bridging basic cell biology with clinical relevance