Publication: ATFS-1 plays no repressive role in the regulation of epidermal immune response.

Publié dans: MicroPubl Biol 2022 ; 2022():

Auteurs: Martineau CN, Maynard CA, Pujol N

Résumé

Fungal infection triggers the induction of antimicrobial peptide (AMP) genes in the epidermis (Pujol et al, 2008). We previously showed that this effect is suppressed by the mitochondrial unfolded protein response (UPRmt), which can be activated by knockdown of select genes including the mitochondrial metalloprotease spg-7 (Zugasti et al, 2016). Here, we confirm that RNAi against spg-7 triggers the UPRmt and blocks AMP induction during infection, whereas infection itself does not trigger the UPRmt. ATFS-1 is a key factor in the UPRmt, mediating much of the associated transcriptional response. We find that, surprisingly, ATFS-1 is not required for the suppression of AMP induction provoked by spg-7(RNAi). These data show that the mitochondrial dysfunction that blocks the immune response upon infection or wounding is independent of ATFS-1.

Lien vers Pubmed [PMID] – 35224461

Lien vers le DOI – 10.17912/micropub.biology.000525