Publication: Layered origins of lymphoid tissue inducer cells.

Publié dans: Immunol Rev 2023 May; 315(1): 71-78

Auteurs: van de Pavert SA

Résumé

The Innate Lymphoid Cell (ILC) family is a relatively recently described immune cell family involved in innate immune responses and tissue homeostasis. Lymphoid Tissue Inducer (LTi) cells are part of the type 3 (ILC3) family. The ILC3 family is the main ILC population within the embryo, in which the LTi cells are critically associated with embryonic lymph node formation. Recent studies have shown more insights in ILC origin and residency from local embryonic and tissue resident precursors. Embryonic LTi cells originating from a different hemogenic endothelial source were shown to be replaced by HSC derived progenitors in adult. This review will discuss the layered origin of the ILC3 family with an emphasis on the LTi cell lineage.

Lien vers Pubmed [PMID] – 36705244

Lien vers HAL – inserm-03965136

Lien vers le DOI – 10.1111/imr.13189