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Immunobiology of Mononuclear Phagocytes

The Lawrence lab studies macrophages and dendritic cells and their roles in cancer. We use sophisticated genetic mouse models and high dimensional proteomic and genomic analysis at single cell and spatial resolution to understand the roles these cells play in shaping the tumour microenvironment and it’s impact on tumour growth and response to therapy. Our previous work has identified macrophage and dendritic cell subsets with pro and anti-tumoral functions and we have mapped molecular pathways that drive their functional polarisation within the tumour microenvironment. We continue to dissect the molecular pathways and cellular mechanisms that drive the functional diversification of these cells with the aim to identify targets for therapeutic intervention.

Hematopoiesis and Inflammation

The Hematopoiesis and Inflammation group joined the Lawrence lab in January 2024, we focus on hematopoietic stem cells and macrophages. The work carried out by Sandrine Sarrazin and Bérengère De Laval explores how hematopoietic stem cells commit to the myeloid lineage, sense pathogens, and establish immune memory, uncovering previously unknown functions in immune responses. Simultaneously, the group explores self-renewal and reprogramming processes in macrophages, examining their roles in inflammation, tissue regeneration, and cancer. This research aims to deepen our understanding of the connections between hematopoietic development, immunity, and regeneration, with potential applications in translational medicine.

Publications

2026
Delfini M, Baudoin E, Guo G, Francois M, Bebien M, Murgaski A, Bettacchioli E, Buferne M, Rastoin O,..., JUN Specifies the Local Differentiation and Maintenance of Pro-tumoral Monocyte-Derived Macrophages., Cancer Res 2026 May; (): .
2026
Fernando W, Clucas J, Rizzo A, Singer R, Goode E, Tiu C, Layzell S, Konecnik J, Wilson R, Wicky John..., Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy., Nat Commun 2026 Mar; 17(1): .
2026
Malfait J, Wan J, Singh HN, Souaid C, Farah G, Su J, Torres M, Manosalva I, Sakakini N, Esnault C, S..., Epromoters bind key stress-related transcription factors to regulate clusters of stress response genes., EMBO J 2026 Feb; 45(3): 901-929.
2026
Eme-Scolan E, Gomes M, Bani A, Romano A, Kassem O, Roussel-Queval A, Casel B, Slimani L, Lawrence T,..., Remodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation., Immunity 2026 Jan; 59(1): 116-128.e7.
2026
Türei D, Schaul J, Palacio-Escat N, Bohár B, Bai Y, Ceccarelli F, Çevrim E, Daley M, Darcan M, Di..., OmniPath: integrated knowledgebase for multi-omics analysis., Nucleic Acids Res 2026 Jan; 54(D1): D652-D660.
2025
Melissa M Lane, Elizabeth Gamage, Shutong Du, Deborah N Ashtree, Amelia J Mcguinness, Sarah Gauci, P..., Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses, BMJ - British Medical Journal.
2025
Lawrence T, Buckley M, Sequence-driven species identification of ZooMS collagen peptide mass fingerprints., J Proteomics 2025 Oct; 321(): 105525.
2025
Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xin Dong, Le Yang, Kexin He, Yanrong Gu, Binhui Zhou, Tingting..., Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression, eLife.
2025
Huang R, Wang Y, Teng H, Xu M, He K, Shen Y, Guo G, Feng X, Li T, Zhou B, Bajenoff M, Lawrence T, Li..., Author Correction: Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells., BMC Biol 2025 Jun; 23(1): 165.
2025
Huang R, Wang Y, Teng H, Xu M, He K, Shen Y, Guo G, Feng X, Li T, Zhou B, Bajenoff M, Lawrence T, Li..., Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells., BMC Biol 2025 May; 23(1): 135.
2025
Wang Y, Dowling SD, Rodriguez V, Maciuch J, Mayer M, Therron T, Shaw TN, Gurra MG, Shah CL, Makinde ..., Comprehensive analysis of myeloid reporter mice., bioRxiv 2025 Feb; (): .
2025
Zhou B, Liu Y, Ma H, Zhang B, Lu B, Li S, Liu T, Qi Y, Wang Y, Zhang M, Qiu J, Fu R, Li W, Lu L, Tia..., Zdhhc1 deficiency mitigates foam cell formation and atherosclerosis by inhibiting PI3K-Akt-mTOR signaling pathway through facilitating the nuclear translocation of p110α., Biochim Biophys Acta Mol Basis Dis 2025 Feb; 1871(2): 167577.
2024
T. Boyer, J. Blunden, R. Dunn, Melanie Ades, Robert Adler, Susheel Adusumilli, W. Agyakwah, Somayeh ..., Introduction, .
2024
Alraies Z, Rivera CA, Delgado MG, Sanséau D, Maurin M, Amadio R, Maria Piperno G, Dunsmore G, Yatim..., Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes., Nat Immunol 2024 Jul; 25(7): 1193-1206.
2024
Daniel Zuleta, Gabriel Arellano, Karina Banda, David Bauman, Kauane M. Bordin, Hannah Carle, Aida Cu..., Unity makes strength: accelerating tropical forest science and building capacity through a global alliance of research networks, .
2024
Georges Aad, Braden Keim Abbott, Dale Abbott, Jalal Abdallah, Kira Abeling, Haider Abidi, Asmaa Abou..., The ATLAS Experiment at the CERN Large Hadron Collider: A Description of the Detector Configuration for Run 3, JINST.
2023
Prashanth Kandalla, Julien Subburayalu, Clément Cocita, Bérengère de Laval, Elena Tomasello, Joha..., M‐CSF directs myeloid and NK cell differentiation to protect from CMV after hematopoietic cell transplantation, EMBO Mol Med 2023 Nov; 15(11): e17694.
2023
Anstee JE, Feehan KT, Opzoomer JW, Dean I, Muller HP, Bahri M, Cheung TS, Liakath-Ali K, Liu Z, Choy..., LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer., Dev Cell 2023 Sep; 58(17): 1548-1561.e10.
2023
Tim Boyer, Ellen Bartow-Gillies, A. Abida, Melanie Ades, Robert Adler, Susheel Adusumilli, W. Agyakw..., Introduction, Bulletin of the American Meteorological Society.
2023
Anderson AC, Robinson AH, Giddens E, Hartshorn B, Allan E, Rowe C, Lawrence T, Chong TT, Lubman DI, ..., Proof-of-concept trial of Goal Management Training+ to improve executive functions and treatment outcomes in methamphetamine use disorder., Drug Alcohol Depend 2023 May; 246(): 109846.
2022
Zhang L, Feng X, Shen Y, Wang Y, Liu Z, Ma Y, Gu Y, Guo G, Duan L, Lu L, Liang Y, Lawrence T, Huang ..., A novel ZsGreen knock-in melanoma cell line reveals the function of CD11b in tumor phagocytosis., Immunol Cell Biol 2022 Oct; 100(9): 691-704.
2022
Zahraa Alraies, Claudia Rivera, Maria-Graciela Delgado, Doriane Sanséau, Mathieu Maurin, Roberto Am..., A Shape Sensing Mechanism driven by Arp2/3 and cPLA 2 licenses Dendritic Cells for Migration to Lymph Nodes in Homeostasis, .
2022
Ganesh Raghu, Martine Remy, Luca Richeldi, Carey C. Thomson, Yoshikazu Inoue, Takeshi Johkoh, Michae..., Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline., American Journal of Respiratory and Critical Care Medicine.
2022
Gregory Lip, Agnieszka Kotalczyk, Christine Teutsch, Hans-Christoph Diener, Sergio Dubner, Jonathan ..., Correction to: Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry, Clinical Research in Cardiology.
2022
Guillot J, Dominici C, Lucchesi A, Nguyen HTT, Puget A, Hocine M, Rangel-Sosa MM, Simic M, Nigri J, ..., Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer., Nat Commun 2022 Apr; 13(1): 1985.
2022
Benoit-Lizon I, Jacquin E, Rivera Vargas T, Richard C, Roussey A, Dal Zuffo L, Martin T, Melis A, Vi..., CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells., J Immunother Cancer 2022 Jan; 10(1): .
2022
Julie Rebejac, Elisa Eme-Scolan, Laurie Arnaud Paroutaud, Sarah Kharbouche, Matei Teleman, Lionel Sp..., Meningeal macrophages protect against viral neuroinfection, <i>Immunity</i>, 2022, 55 (11), pp.2103-2117.e10. <a target="_blank" href="https://dx.doi.org/10.1016/j.immuni.2022.10.005">⟨10.1016/j.immuni.2022.10.005⟩</a>.
2022
Gu Y, Lawrence T, Mohamed R, Liang Y, Yahaya BH, The emerging roles of interstitial macrophages in pulmonary fibrosis: A perspective from scRNA-seq analyses., Front Immunol 2022 ; 13(): 923235.
2021
Vasiliki Lagou, Reedik Mägi, Jouke- Jan Hottenga, Harald Grallert, John Perry, Nabila Bouatia-Naji,..., Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability, Nature Communications.
2021
Opzoomer JW, Anstee JE, Dean I, Hill EJ, Bouybayoune I, Caron J, Muliaditan T, Gordon P, Sosnowska D..., Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression., Sci Adv 2021 Nov; 7(45): eabg9518.
2021
Chao T, Lu L, Zhang L, Huang R, Liu Z, Zhou B, Kong E, Zhang Z, Lawrence T, Liang Y, An inducible model for specific neutrophil depletion by diphtheria toxin in mice., Sci China Life Sci 2021 Aug; 64(8): 1227-1235.
2021
Ghislat G, Cheema AS, Baudoin E, Verthuy C, Ballester PJ, Crozat K, Attaf N, Dong C, Milpied P, Mali..., NF-κB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity., Sci Immunol 2021 Jul; 6(61): .
2021
George Ntaios, Menno Huisman, Hans-Christoph Diener, Jonathan Halperin, Christine Teutsch, Sabrina M..., Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry, The Hellenic Journal of Cardiology.
2021
Wilkinson H, Leonard H, Chen D, Lawrence T, Robson M, Goossens P, McVey JH, Dorling A, PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses., iScience 2021 Jan; 24(1): 101981.
2021
Vasiliki Lagou, Reedik Mägi, Jouke-Jan Hottenga, Harald Grallert, John R. B. Perry, Nabila Bouatia-..., Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability, Nature Communications.
2021
Zhou B, Lawrence T, Liang Y, The Role of Plasmacytoid Dendritic Cells in Cancers., Front Immunol 2021 ; 12(): 749190.
2020
Anders Etzerodt, Morgane Moulin, Thomas Koed Doktor, Marcello Delfini, Noushine Mossadegh, Marc Baje..., Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer, J Exp Med 2020 Apr; 217(4): .
2020
Tilstam PV, Soppert J, Hemmers C, Harlacher E, Döring Y, van der Vorst EPC, Schulte C, Alampour-Raj..., Non-activatable mutant of inhibitor of kappa B kinase α (IKKα) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice., Atherosclerosis 2020 Jan; 292(): 23-30.
2019
Huang R, Guo G, Lu L, Fu R, Luo J, Liu Z, Gu Y, Yang W, Zheng Q, Chao T, He L, Wang Y, Niu Z, Wang H..., The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis., J Lipid Res 2019 Dec; 60(12): 2006-2019.
2019
Cassol F, Portal L, Richelme S, Dupont M, Boursier Y, Arechederra M, Auphan-Anezin N, Chasson L, Lap..., Tracking Dynamics of Spontaneous Tumors in Mice Using Photon-Counting Computed Tomography., iScience 2019 Nov; 21(): 68-83.
2019
Goossens P, Rodriguez-Vita J, Etzerodt A, Masse M, Rastoin O, Gouirand V, Ulas T, Papantonopoulou O,..., Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression., Cell Metab 2019 Jun; 29(6): 1376-1389.e4.
2019
Chao T, Liu Z, Zhang Y, Zhang L, Huang R, He L, Gu Y, Chen Z, Zheng Q, Shi L, Zheng W, Qi X, Kong E,..., Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice., Front Genet 2019 ; 10(): 124.
2019
Gregory Verdeil, Toby Lawrence, Anne-Marie Schmitt-Verhulst, Nathalie Auphan-Anezin, Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy, <i>Contemporary Southeast Asia</i>, 2019, 11 (12), <a target="_blank" href="https://dx.doi.org/10.3390/cancers11121832">⟨10.3390/cancers11121832⟩</a>.
2019
Anders Etzerodt, Kyriaki Tsalkitzi, Maciej Maniecki, William Damsky, Marcello Delfini, Elodie Baudoi..., Specific targeting of CD163(+) TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression, <i>Journal of Experimental Medicine</i>, 2019, 216 (10), pp.2394-2411. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20182124">⟨10.1084/jem.20182124⟩</a>.
2019
William Busse, Peter Barker, Stephanie Sproule, Richard Olsson, Ubaldo Martin, Mitchell Goldman, Ana..., Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial, The Lancet Respiratory Medicine.
2018
Priyanka Parmar, Estelle Lowry, Giovanni Cugliari, Matthew Suderman, Rory Wilson, Ville Karhunen, To..., Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults, EBioMedicine.
2018
Ghislat G, Lawrence T, Autophagy in dendritic cells., Cell Mol Immunol 2018 Nov; 15(11): 944-952.
2018
Villeneuve DL, Landesmann B, Allavena P, Ashley N, Bal-Price A, Corsini E, Halappanavar S, Hussell T..., Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways., Toxicol Sci 2018 Jun; 163(2): 346-352.
2018
Verzella D, Bennett J, Fischietti M, Thotakura AK, Recordati C, Pasqualini F, Capece D, Vecchiotti D..., GADD45β Loss Ablates Innate Immunosuppression in Cancer., Cancer Res 2018 Mar; 78(5): 1275-1292.
2018
Elena Tomasello, Karima Naciri, Rabie Chelbi, Gilles Bessou, Anissa Fries, Elise Gressier, Abdenour ..., Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection, EMBO J 2018 Oct; 37(19): .
2017
Habbeddine M, Verthuy C, Rastoin O, Chasson L, Bebien M, Bajenoff M, Adriouch S, den Haan JMM, Penni..., Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone., Cell Rep 2017 Nov; 21(9): 2515-2527.
2017
Cortés M, Sanchez-Moral L, de Barrios O, Fernández-Aceñero MJ, Martínez-Campanario MC, Esteve-Co..., Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles., EMBO J 2017 Nov; 36(22): 3336-3355.
2017
Lee CY, Lai TY, Tsai MK, Chang YC, Ho YH, Yu IS, Yeh TW, Chou CC, Lin YS, Lawrence T, Hsu LC, The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation., Nat Commun 2017 Jun; 8(): 15502.
2017
Etzerodt A, Berg RM, Plovsing RR, Andersen MN, Bebien M, Habbeddine M, Lawrence T, Møller HJ, Moest..., Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of ‘soluble CD163’ in plasma., Sci Rep 2017 Jan; 7(): 40286.
2017
van der Vorst EPC, Theodorou K, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LFA, Ta..., High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling., Cell Metab 2017 Jan; 25(1): 197-207.
2016
Lawrence T, Coordinated Regulation of Signaling Pathways during Macrophage Activation., Microbiol Spectr 2016 Oct; 4(5): .
2016
Fan R, Toubal A, Goñi S, Drareni K, Huang Z, Alzaid F, Ballaire R, Ancel P, Liang N, Damdimopoulos ..., Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes., Nat Med 2016 Jul; 22(7): 780-91.
2016
Pathricia V. Tilstam, Wendy Theelen, Setareh Alampour-Sarabi, Lukas Pawig, Yaw Asare, Yvonne Doering..., NON-ACTIVATABLE MUTANT OF INHIBITOR OF KAPPA B KINASE alpha (IKK alpha) EXERTS SITE-SPECIFIC EFFECTS ON ATHEROSCLEROSIS, <i>Nephrology Dialysis Transplantation</i>, 2016, 31 (1), pp.48.
2016
Cristian Pattaro, Alexander Teumer, Mathias Gorski, Audrey Y Chu, Man Li, Vladan Mijatovic, Maija Ga..., Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function, Nature Communications.
2015
Kuijpers MJ, Mattheij NJ, Cipolla L, van Geffen JP, Lawrence T, Donners MM, Boon L, Lievens D, Torti..., Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α., Arterioscler Thromb Vasc Biol 2015 Jun; 35(6): 1374-81.
2015
Baratin M, Foray C, Demaria O, Habbeddine M, Pollet E, Maurizio J, Verthuy C, Davanture S, Azukizawa..., Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance., Immunity 2015 Apr; 42(4): 627-39.
2014
Zhang J, Clark K, Lawrence T, Peggie MW, Cohen P, An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation., Biochem J 2014 Aug; 461(3): 531-7.
2014
Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, ..., Macrophage activation and polarization: nomenclature and experimental guidelines., Immunity 2014 Jul; 41(1): 14-20.
2014
Dalod M, Chelbi R, Malissen B, Lawrence T, Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming., EMBO J 2014 May; 33(10): 1104-16.
2014
Tilstam PV, Gijbels MJ, Habbeddine M, Cudejko C, Asare Y, Theelen W, Zhou B, Döring Y, Drechsler M,..., Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice., PLoS One 2014 ; 9(2): e87452.
2013
Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, C..., I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection., EMBO J 2013 Mar; 32(6): 816-28.
2013
Rastrick JM, Stevenson CS, Eltom S, Grace M, Davies M, Kilty I, Evans SM, Pasparakis M, Catley MC, L..., Cigarette smoke induced airway inflammation is independent of NF-κB signalling., PLoS One 2013 ; 8(1): e54128.
2012
Magali Bebien, Mary Hensler, Suzel Davanture, Li-Chung Hsu, Michael Karin, Jin Mo Park, Lena Alexopo..., The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity, PLoS Pathogens.
2012
Robert A. Scott, Vasiliki Lagou, Ryan P. Welch, Eleanor Wheeler, May E. Montasser, Jian'An Luan, Ree..., Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways, Nature Genetics.
2012
Martien A. M. Groenen, Alan L. Archibald, Hirohide Uenishi, Christopher K. Tuggle, Yasuhiro Takeuchi..., Analyses of pig genomes provide insight into porcine demography and evolution, Nature.
2012
Alisa K. Manning, Marie-France Hivert, Robert A. Scott, Jonna L. Grimsby, Nabila Bouatia-Naji, Han C..., A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance, Nature Genetics.
2011
Lawrence T, Natoli G, Transcriptional regulation of macrophage polarization: enabling diversity with identity., Nat Rev Immunol 2011 Oct; 11(11): 750-61.
2011
Lawrence T, Macrophages and NF-κB in cancer., Curr Top Microbiol Immunol 2011 ; 349(): 171-84.
2010
Lawrence T, Fong C, The resolution of inflammation: anti-inflammatory roles for NF-kappaB., Int J Biochem Cell Biol 2010 Apr; 42(4): 519-23.
2010
Rodriguez-Vita J, Lawrence T, The resolution of inflammation and cancer., Cytokine Growth Factor Rev 2010 Feb; 21(1): 61-5.
2010
Mancino A, Lawrence T, Nuclear factor-kappaB and tumor-associated macrophages., Clin Cancer Res 2010 Feb; 16(3): 784-9.
2009
Lawrence T, The nuclear factor NF-kappaB pathway in inflammation., Cold Spring Harb Perspect Biol 2009 Dec; 1(6): a001651.
2009
Charles KA, Kulbe H, Soper R, Escorcio-Correia M, Lawrence T, Schultheis A, Chakravarty P, Thompson ..., The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans., J Clin Invest 2009 Oct; 119(10): 3011-23.
2009
Hagemann T, Biswas SK, Lawrence T, Sica A, Lewis CE, Regulation of macrophage function in tumors: the multifaceted role of NF-kappaB., Blood 2009 Apr; 113(14): 3139-46.
2009
Hagemann T, Lawrence T, Investigating macrophage and malignant cell interactions in vitro., Methods Mol Biol 2009 ; 512(): 325-32.
2008
Kim C, Sano Y, Todorova K, Carlson BA, Arpa L, Celada A, Lawrence T, Otsu K, Brissette JL, Arthur JS..., The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression., Nat Immunol 2008 Sep; 9(9): 1019-27.
2008
Fong CH, Bebien M, Didierlaurent A, Nebauer R, Hussell T, Broide D, Karin M, Lawrence T, An antiinflammatory role for IKKbeta through the inhibition of “classical” macrophage activation., J Exp Med 2008 Jun; 205(6): 1269-76.
2008
Hagemann T, Lawrence T, McNeish I, Charles KA, Kulbe H, Thompson RG, Robinson SC, Balkwill FR, “Re-educating” tumor-associated macrophages by targeting NF-kappaB., J Exp Med 2008 Jun; 205(6): 1261-8.
2008
Rajakariar R, Lawrence T, Bystrom J, Hilliard M, Colville-Nash P, Bellingan G, Fitzgerald D, Yaqoob ..., Novel biphasic role for lymphocytes revealed during resolving inflammation., Blood 2008 Apr; 111(8): 4184-92.
2008
Didierlaurent A, Goulding J, Patel S, Snelgrove R, Low L, Bebien M, Lawrence T, van Rijt LS, Lambrec..., Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection., J Exp Med 2008 Feb; 205(2): 323-9.
2007
Rajakariar R, Hilliard M, Lawrence T, Trivedi S, Colville-Nash P, Bellingan G, Fitzgerald D, Yaqoob ..., Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2., Proc Natl Acad Sci U S A 2007 Dec; 104(52): 20979-84.
2007
Hagemann T, Balkwill F, Lawrence T, Inflammation and cancer: a double-edged sword., Cancer Cell 2007 Oct; 12(4): 300-1.
2007
Lawrence T, Hageman T, Balkwill F, Cancer. Sex, cytokines, and cancer., Science 2007 Jul; 317(5834): 51-2.
2007
Fleetwood AJ, Lawrence T, Hamilton JA, Cook AD, Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation., J Immunol 2007 Apr; 178(8): 5245-52.
2007
Lawrence T, Inflammation and cancer: a failure of resolution?, Trends Pharmacol Sci 2007 Apr; 28(4): 162-5.
2007
Lawrence T, Gilroy DW, Chronic inflammation: a failure of resolution?, Int J Exp Pathol 2007 Apr; 88(2): 85-94.
2007
. Drosophila 12 Genomes Consortium, Andrew G Clark, Michael B Eisen, Douglas R Smith, Casey M Bergma..., Evolution of genes and genomes on the Drosophila phylogeny, Nature.
2006
Abraham SM, Lawrence T, Kleiman A, Warden P, Medghalchi M, Tuckermann J, Saklatvala J, Clark AR, Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1., J Exp Med 2006 Aug; 203(8): 1883-9.
2006
Karin M, Lawrence T, Nizet V, Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer., Cell 2006 Feb; 124(4): 823-35.
2005
Broide DH, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, Karin M, Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium., Proc Natl Acad Sci U S A 2005 Dec; 102(49): 17723-8.
2005
Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M, I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss., J Exp Med 2005 May; 201(10): 1677-87.
2005
Lawrence T, Bebien M, Liu GY, Nizet V, Karin M, IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation., Nature 2005 Apr; 434(7037): 1138-43.
2004
Liu GY, Doran KS, Lawrence T, Turkson N, Puliti M, Tissi L, Nizet V, Sword and shield: linked group B streptococcal beta-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense., Proc Natl Acad Sci U S A 2004 Oct; 101(40): 14491-6.
2004
Blackwell NM, Sembi P, Newson JS, Lawrence T, Gilroy DW, Kabouridis PS, Reduced infiltration and increased apoptosis of leukocytes at sites of inflammation by systemic administration of a membrane-permeable IkappaBalpha repressor., Arthritis Rheum 2004 Aug; 50(8): 2675-84.
2004
Gilroy DW, Lawrence T, Perretti M, Rossi AG, Inflammatory resolution: new opportunities for drug discovery., Nat Rev Drug Discov 2004 May; 3(5): 401-16.
2003
Gilroy DW, Colville-Nash PR, McMaster S, Sawatzky DA, Willoughby DA, Lawrence T, Inducible cyclooxygenase-derived 15-deoxy(Delta)12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis., FASEB J 2003 Dec; 17(15): 2269-71.
2003
Colville-Nash P, Lawrence T, Air-pouch models of inflammation and modifications for the study of granuloma-mediated cartilage degradation., Methods Mol Biol 2003 ; 225(): 181-9.
2002
Lawrence T, Willoughby DA, Gilroy DW, Anti-inflammatory lipid mediators and insights into the resolution of inflammation., Nat Rev Immunol 2002 Oct; 2(10): 787-95.
2002
Kabouridis PS, Hasan M, Newson J, Gilroy DW, Lawrence T, Inhibition of NF-kappa B activity by a membrane-transducing mutant of I kappa B alpha., J Immunol 2002 Sep; 169(5): 2587-93.

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