Bertrand NADEL – CIML

Recherche

Thème

À propos

Director of the Cancéropôle PACA
Member of the Henry Kunkel Society
Member of the American Society of Haematology

Projets

CPC_profile: Caractérisation et Ciblage des Cellules Précurseurs Cancéreuses (CPC) à l’origine des rechutes dans les lymphomes B

La progression du lymphome folliculaire est marquée par des cycles iteratifs de rémission et de rechute, ces dernières résultant généralement de la […]

Sandrine ROULLAND

LYMPHOMATLAS: un atlas des lymphomes B à l’échelle de la cellule unique

Project : LYMPHOMATLAS Des études multi-omiques en cellule unique dans les lymphomes B ont permis de mettre en lumière un […]

Sandrine ROULLAND

Validation, adaptation et développement en routine clinique d’un biomarqueur single-cell stratifiant les patients FL de haut-risque

Les patients atteints de lymphome folliculaire (LF) présentent une très grande hétérogénéité biologique impactant fortement la réponse aux thérapies actuelles. […]

Sandrine ROULLAND

Publications

Mélanie Collin, Guillemette Gagey, Vignesh Shanmugam, Abner Louissaint, Jessica Okosun, Clementine ..., Follicular lymphoma research: an open dialogue for a collaborative roadmap, <i>Histopathology</i>, 2024, 86 (1), pp.79-93. <a target="_blank" href="https://dx.doi.org/10.1111/his.15344">⟨10.1111/his.15344⟩</a>.

Sabrina Baaklini, Alexandre Sarrabay, Camille Barthelemy, Laila Dahbi, Laurine Gil, Noushin Mossadeg..., A Single Cell Atlas of Diffuse Large B Cell Lymphomas Reveals Distinct Cellular States Predictive of Outcomes., <i>65th American Society of Hematology (ASH) Annual Meeting and Exposition</i>, Dec 2023, San diego, CA, United States. pp.848 - 848, <a target="_blank" href="https://dx.doi.org/10.1182/blood-2023-173929">⟨10.1182/blood-2023-173929⟩</a>.

Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, de Oliveira Araujo IB, Berti E, Bhagat G, Borg..., Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720-1748., Leukemia 2023 Sep; 37(9): 1944-1951.

Joseph G Schroers-Martin, Joanne Soo, Gabriel Brisou, Florian Scherer, David M Kurtz, Brian J Sworde..., Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors, <i>Cancer Discovery</i>, 2023, 13 (6), pp.1310-1323. <a target="_blank" href="https://dx.doi.org/10.1158/2159-8290.CD-23-0111">⟨10.1158/2159-8290.CD-23-0111⟩</a>.

de Laval B, Maurizio J, Kandalla PK, Brisou G, Simonnet L, Huber C, Gimenez G, Matcovitch-Natan O, R..., C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells., Cell Stem Cell 2023 Jan; 30(1): 112.

Alicia Beyou, Simon Leonard, Ilenia Papa, Noushin Mossadegh-Keller, Sabrina Baaklini, Lionel Spinell..., Single-Cell Longitudinal Characterization of FL Heterogeneity and Residual Disease in the Bone Marrow from Low-Tumor Burden FL Enrolled in the Flirt Clinical Trial, <i>65th ASH Annual Meeting</i>, Dec 2023, San Diego, United States. pp.852, <a target="_blank" href="https://dx.doi.org/10.1182/blood-2023-186070">⟨10.1182/blood-2023-186070⟩</a>.

Estelle Balducci, Thomas Steimlé, Charlotte Smith, Patrick Villarese, Mélanie Feroul, Dominique Pa..., TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2, <i>Molecular Cancer</i>, 2023, 22 (1), pp.108. <a target="_blank" href="https://dx.doi.org/10.1186/s12943-023-01794-y">⟨10.1186/s12943-023-01794-y⟩</a>.

de Leval L, Alizadeh AA, Bergsagel PL, Campo E, Davies A, Dogan A, Fitzgibbon J, Horwitz SM, Melnick..., Genomic profiling for clinical decision making in lymphoid neoplasms., Blood 2022 Nov; 140(21): 2193-2227.

Martin Dreyling, Marc André, Nicola Gökbuget, Hervé Tilly, Mats Jerkeman, John Gribben, Andrés F..., The EHA Research Roadmap: Malignant Lymphoid Diseases, <i>HemaSphere</i>, 2022, 6, <a target="_blank" href="https://dx.doi.org/10.1097/hs9.0000000000000726">⟨10.1097/hs9.0000000000000726⟩</a>.

Noushin Mossadegh-Keller, Gabriel Brisou, Alicia Beyou, Bertrand Nadel, Sandrine Roulland, Human B Lymphomas Reveal Their Secrets Through Genetic Mouse Models, <i>Frontiers in Immunology</i>, 2021, 12, <a target="_blank" href="https://dx.doi.org/10.3389/fimmu.2021.683597">⟨10.3389/fimmu.2021.683597⟩</a>.

Mathis Nozais, Marie Loosveld, Saran Pankaew, Clémence Grosjean, Noémie Gentil, Julie Quessada, Be..., MYC deficiency impairs the development of effector/memory T lymphocytes, <i>iScience</i>, 2021, 24 (7), pp.102761. <a target="_blank" href="https://dx.doi.org/10.1016/j.isci.2021.102761">⟨10.1016/j.isci.2021.102761⟩</a>.

Gabriel Brisou, Bertrand Nadel, Sandrine Roulland, The Premalignant Ancestor Cell of t(14;18)+ Lymphoma, <i>HemaSphere</i>, 2021, 5 (6), pp.e579. <a target="_blank" href="https://dx.doi.org/10.1097/HS9.0000000000000579">⟨10.1097/HS9.0000000000000579⟩</a>.

Milpied P, Gandhi AK, Cartron G, Pasqualucci L, Tarte K, Nadel B, Roulland S, Follicular lymphoma dynamics., Adv Immunol 2021 ; 150(): 43-103.

de Laval B, Maurizio J, Kandalla PK, Brisou G, Simonnet L, Huber C, Gimenez G, Matcovitch-Natan O, R..., C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells., Cell Stem Cell 2020 May; 26(5): 793.

Bérengère de Laval, Julien Maurizio, Prashanth Kandalla, Gabriel Brisou, Louise Simonnet, Caroline..., C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells, <i>Cell Stem Cell</i>, 2020, 26 (5), pp.657-674.e8. <a target="_blank" href="https://dx.doi.org/10.1016/j.stem.2020.01.017">⟨10.1016/j.stem.2020.01.017⟩</a>.

Emeline Mollaret, Ugo Tomas, Emmanuel Gomez, Bertrand Nadel, Lucile Baseggio, E Blasco, Gabriel Bris..., CeVi: une collection unique de CELLULES VIABLES humaines cryopréservées de patients atteints de LYMPHOMES, une initiative pour accélérer l’innovation et son transfert dans le domaine du LYMPHOME., <i>SFH</i>, 2020, Paris, France.

Johanna Chiche, Julie Reverso-Meinietti, Annabelle Mouchotte, Camila Rubio-Patino, Rana Mhaidly, Elo..., GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors, <i>CELL METABOLISM</i>, 2019, 29 (6), pp.1243+. <a target="_blank" href="https://dx.doi.org/10.1016/j.cmet.2019.02.002">⟨10.1016/j.cmet.2019.02.002⟩</a>.

Milpied P, Cervera-Marzal I, Mollichella ML, Tesson B, Brisou G, Traverse-Glehen A, Salles G, Spinel..., Human germinal center transcriptional programs are de-synchronized in B cell lymphoma., Nat Immunol 2018 Sep; 19(9): 1013-1024.

Stéphanie Gon, Marie Loosveld, Thomas Crouzet, Delphine Potier, Mélanie Bonnet, Stéphanie Morin, ..., Fit αβ T-Cell Receptor suppresses leukemogenesis of Pten-deficient thymocytes., <i>Haematologica</i>, 2018, <a target="_blank" href="https://dx.doi.org/10.3324/haematol.2018.188359">⟨10.3324/haematol.2018.188359⟩</a>.

Gascoyne RD, Nadel B, Pasqualucci L, Fitzgibbon J, Payton JE, Melnick A, Weigert O, Tarte K, Gribben..., Follicular lymphoma: State-of-the-art ICML workshop in Lugano 2015., Hematol Oncol 2017 Dec; 35(4): 397-407.

Balducci E, Nivaggioni V, Boudjarane J, Bouriche L, Rahal I, Bernot D, Alazard E, Duployez N, Grarde..., Lineage switch from B acute lymphoblastic leukemia to acute monocytic leukemia with persistent t(4;11)(q21;q23) and cytogenetic evolution under CD19-targeted therapy., Ann Hematol 2017 Sep; 96(9): 1579-1581.

Aurelie Gagnaire, Bertrand Nadel, Didier Raoult, Jacques Neefjes, Jean-Pierre Gorvel, Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer, <i>Nature Reviews Microbiology</i>, 2017, 15 (2), pp.109-128. <a target="_blank" href="https://dx.doi.org/10.1038/nrmicro.2016.171">⟨10.1038/nrmicro.2016.171⟩</a>.

Mohamed Amine Hamouda, Arnaud Jacquel, Guillaume Robert, Alexandre Puissant, Valentine Richez, Romé..., BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice, <i>Journal of Experimental Medicine</i>, 2016, [Epub ahead of print]. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20150983">⟨10.1084/jem.20150983⟩</a>.

Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, de Wit TD, Eichinger S, Fibbe W,..., The European Hematology Association Roadmap for European Hematology Research: a consensus document., Haematologica 2016 Feb; 101(2): 115-208.

Clea Melenotte, Matthieu Million, Gilles Audoly, Audrey Gorse, Herve Dutronc, Gauthier Roland, Micha..., B-cell non-Hodgkin lymphoma linked to Coxiella burnetii, <i>Blood</i>, 2016, 127 (1), pp.113-121. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2015-04-639617">⟨10.1182/blood-2015-04-639617⟩</a>.

Milpied P, Nadel B, Roulland S, Premalignant cell dynamics in indolent B-cell malignancies., Curr Opin Hematol 2015 Jul; 22(4): 388-96.

Mamessier E, Drevet C, Broussais-Guillaumot F, Mollichella ML, Garciaz S, Roulland S, Benchetrit M, ..., Contiguous follicular lymphoma and follicular lymphoma in situ harboring N-glycosylated sites., Haematologica 2015 Apr; 100(4): e155-7.

Emilie Mamessier, Charlotte Drevet, Florence Broussais-Guillaumot, Marie-Laure Mollichella, Sylvain ..., Contiguous follicular lymphoma and follicular lymphoma in situ harboring N-glycosylated sites, <i>Haematologica</i>, 2015, 100, pp.E155-E157.

Roulland S, Nadel B, [Follicular lymphoma: a history of perversion of immunological memory]., Med Sci (Paris) 2015 Apr; 31(4): 360-2.

Navarro JM, Touzart A, Pradel LC, Loosveld M, Koubi M, Fenouil R, Le Noir S, Maqbool MA, Morgado E, ..., Site- and allele-specific polycomb dysregulation in T-cell leukaemia., Nat Commun 2015 Jan; 6(): 6094.

Stéphanie Sungalee, Emilie Mamessier, Ester Morgado, Emilie Grégoire, Philip Brohawn, Christopher ..., Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression, <i>Journal of Clinical Investigation</i>, 2014, 124 (12), pp.5337-5351. <a target="_blank" href="https://dx.doi.org/10.1172/JCI72415">⟨10.1172/JCI72415⟩</a>.

Agata Cieslak, Sandrine Le Noir, Amélie Trinquand, Ludovic Lhermitte, Don-Marc Franchini, Patrick V..., RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement, <i>Journal of Experimental Medicine</i>, 2014, 211 (9), pp.1821--1832. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20132585">⟨10.1084/jem.20132585⟩</a>.

Loosveld M, Castellano R, Gon S, Goubard A, Crouzet T, Pouyet L, Prebet T, Vey N, Nadel B, Collette ..., Therapeutic targeting of c-Myc in T-cell acute lymphoblastic leukemia, T-ALL., Oncotarget 2014 May; 5(10): 3168-72.

Roulland S, Kelly RS, Morgado E, Sungalee S, Solal-Celigny P, Colombat P, Jouve N, Palli D, Pala V, ..., t(14;18) Translocation: A predictive blood biomarker for follicular lymphoma., J Clin Oncol 2014 May; 32(13): 1347-55.

Mamessier E, Broussais-Guillaumot F, Chetaille B, Bouabdallah R, Xerri L, Jaffe ES, Nadel B, Nature and importance of follicular lymphoma precursors., Haematologica 2014 May; 99(5): 802-10.

Mamessier E, Song JY, Eberle FC, Pack S, Drevet C, Chetaille B, Abdullaev Z, Adelaïde J, Birnbaum D..., Early lesions of follicular lymphoma: a genetic perspective., Haematologica 2014 Mar; 99(3): 481-8.

Julie Tellier, Cédric Ménard, Sandrine Roulland, Céline Monvoisin, Lionel Chasson, Bertrand Nadel..., Human t(14;18)positive germinal center B cells: a new step in follicular lymphoma pathogenesis?, <i>Blood</i>, 2014, 123 (22), pp.3462-3465. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2013-12-545954">⟨10.1182/blood-2013-12-545954⟩</a>.

Marie Loosveld, Mélanie Bonnet, Stéphanie Gon, Bertrand Montpellier, Benoit Quilichini, Jean-Marc ..., MYC fails to efficiently shape malignant transformation in T-cell acute lymphoblastic leukemia., <i>Genes, Chromosomes & Cancer</i>, 2014, 53 (1), pp.52-66. <a target="_blank" href="https://dx.doi.org/10.1002/gcc.22117">⟨10.1002/gcc.22117⟩</a>.

Amélie Trinquand, Aline Tanguy-Schmidt, Raouf Ben Abdelali, Jérôme Lambert, Kheira Beldjord, Etie..., Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study., <i>Journal of Clinical Oncology</i>, 2013, 31 (34), pp.4333-42. <a target="_blank" href="https://dx.doi.org/10.1200/JCO.2012.48.5292">⟨10.1200/JCO.2012.48.5292⟩</a>.

Neven B, Mamessier E, Bruneau J, Kaltenbach S, Kotlarz D, Suarez F, Masliah-Planchon J, Billot K, Ca..., A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency., Blood 2013 Nov; 122(23): 3713-22.

Le Noir S, Ben Abdelali R, Lelorch M, Bergeron J, Sungalee S, Payet-Bornet D, Villarèse P, Petit A,..., Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL., Blood 2012 Oct; 120(16): 3298-309.

Dadi S, Le Noir S, Payet-Bornet D, Lhermitte L, Zacarias-Cabeza J, Bergeron J, Villarèse P, Vachez ..., TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression., Cancer Cell 2012 Apr; 21(4): 563-76.

Mélanie Bonnet, Marie Loosveld, Bertrand Montpellier, Jean-Marc Navarro, Benoit Quilichini, Christo..., Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia, <i>Blood</i>, 2011, 117 (24), pp.6650-6659. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2011-02-336842">⟨10.1182/blood-2011-02-336842⟩</a>.

Sandrine Roulland, Mustapha Faroudi, Emilie Mamessier, Stéphanie Sungalee, Gilles Salles, Bertrand ..., Early Steps of Follicular Lymphoma Pathogenesis, <i>Advances in Immunology</i>, 111, Elsevier, pp.1-46, 2011, Advances in Immunology, <a target="_blank" href="https://dx.doi.org/10.1016/B978-0-12-385991-4.00001-5">⟨10.1016/B978-0-12-385991-4.00001-5⟩</a>.

Katrina Vanura, Maruska Marusic Vrsalovic, Trang Le, Rodrig Marculescu, Rajko Kusec, Ulrich Jäger, ..., V(D)J targeting mistakes occur at low frequency in acute lymphoblastic leukemia., <i>Genes, Chromosomes & Cancer</i>, 2009, 48 (8), pp.725-36. <a target="_blank" href="https://dx.doi.org/10.1002/gcc.20677">⟨10.1002/gcc.20677⟩</a>.

Julie Agopian, Jean-Marc Navarro, Anne-Claire Gac, Yannick Lecluse, Mélanie Briand, Pierre Grenot, ..., Agricultural pesticide exposure and the molecular connection to lymphomagenesis., <i>Journal of Experimental Medicine</i>, 2009, 206 (7), pp.1473-83. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20082842">⟨10.1084/jem.20082842⟩</a>.

Sandrine Roulland, Bertrand Nadel, [The profiling era: towards innovative approaches for tailored therapy], <i>Médecine/Sciences</i>, 2009, 25 (6-7), pp.553-5.

Roulland S, Nadel B, [The profiling era: towards innovative approaches for tailored therapy]., Med Sci (Paris) 2009 ; 25(6-7): 553-5.

Roulland S, Suarez F, Hermine O, Nadel B, Pathophysiological aspects of memory B-cell development., Trends Immunol 2008 Jan; 29(1): 25-33.

Sandrine Roulland, Felipe Suarez, Olivier Hermine, Bertrand Nadel, Pathophysiological aspects of memory B-cell development., <i>Trends in Immunology</i>, 2008, 29 (1), pp.25-33. <a target="_blank" href="https://dx.doi.org/10.1016/j.it.2007.10.005">⟨10.1016/j.it.2007.10.005⟩</a>.

Willem A Dik, Bertrand Nadel, Grzegorz K Przybylski, Vahid Asnafi, Piotr Grabarczyk, Jean Marc Navar..., Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL., <i>Blood</i>, 2007, 110 (1), pp.388-92. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2006-12-064816">⟨10.1182/blood-2006-12-064816⟩</a>.

Susanna Fischer, Georg Mann, Marianne Konrad, Markus Metzler, Georg Ebetsberger, Neil Jones, Bertran..., Screening for leukemia- and clone-specific markers at birth in children with T cell precursor ALL suggests a predominantly postnatal origin., <i>Blood</i>, 2007, Epub ahead of print. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2007-03-077339">⟨10.1182/blood-2007-03-077339⟩</a>.

Emmanuelle Clappier, Wendy Cuccuini, Anna Kalota, Antoine Crinquette, Jean-Michel Cayuela, Willem A ..., The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL) – the translocation defining a new T-ALL subtype in very young children., <i>Blood</i>, 2007, Epub ahead of print. <a target="_blank" href="https://dx.doi.org/10.1182/blood-2006-12-064683">⟨10.1182/blood-2006-12-064683⟩</a>.

Katrina Vanura, Bertrand Montpellier, Trang Le, Salvatore Spicuglia, Jean-Marc Navarro, Olivier Caba..., In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability., <i>PLoS Biology</i>, 2007, 5 (3), pp.e43. <a target="_blank" href="https://dx.doi.org/10.1371/journal.pbio.0050043">⟨10.1371/journal.pbio.0050043⟩</a>.

Vanura K, Montpellier B, Le T, Spicuglia S, Navarro JM, Cabaud O, Roulland S, Vachez E, Prinz I, Fer..., In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability., PLoS Biol 2007 Mar; 5(3): e43.

Sandrine Roulland, Jean-Marc Navarro, Pierre Grenot, Michèle Milili, Julie Agopian, Bertrand Montpe..., Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis., <i>Journal of Experimental Medicine</i>, 2006, 203 (11), pp.2425-31. <a target="_blank" href="https://dx.doi.org/10.1084/jem.20061292">⟨10.1084/jem.20061292⟩</a>.

Roulland S, Navarro JM, Grenot P, Milili M, Agopian J, Montpellier B, Gauduchon P, Lebailly P, Schif..., Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis., J Exp Med 2006 Oct; 203(11): 2425-31.

Rodrig Marculescu, Katrina Vanura, Bertrand Montpellier, Sandrine Roulland, Trang Le, Jean-Marc Nava..., Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures., <i>DNA Repair</i>, 2006, 5 (9-10), pp.1246-58. <a target="_blank" href="https://dx.doi.org/10.1016/j.dnarep.2006.05.015">⟨10.1016/j.dnarep.2006.05.015⟩</a>.

Marculescu R, Vanura K, Montpellier B, Roulland S, Le T, Navarro JM, Jäger U, McBlane F, Nadel B, Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures., DNA Repair (Amst) 2006 Sep; 5(9-10): 1246-58.

Langerak AW, Nadel B, De Torbal A, Wolvers-Tettero IL, van Gastel-Mol EJ, Verhaaf B, Jäger U, van D..., Unraveling the consecutive recombination events in the human IGK locus., J Immunol 2004 Sep; 173(6): 3878-88.

Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B, Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL., Nat Genet 2003 Mar; 33(3): 342-4.

Marculescu R, Le T, Simon P, Jaeger U, Nadel B, V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites., J Exp Med 2002 Jan; 195(1): 85-98.

Bertrand Nadel, Alan Tang, Guia Escuro, Geanncarlo Lugo, Ann Feeney, Sequence of the Spacer in the Recombination Signal Sequence Affects V(D)J Rearrangement Frequency and Correlates with Nonrandom Vκ Usage In Vivo, <i>Journal of Experimental Medicine</i>, 1998, 187 (9), pp.1495-1503. <a target="_blank" href="https://dx.doi.org/10.1084/jem.187.9.1495">⟨10.1084/jem.187.9.1495⟩</a>.